Covid-19 Sentry

Contents

• From Preprints
• From Clinical Trials
• From PubMed
• From Patent Search

From Preprints

• Strategies of University Students to Cope with COVID-19 and the Role of Psychological Flexibility -
  The COVID-19 outbreak is an important stress factor that threatens the health of individuals both physically and psychologically. Within the scope of struggling the outbreak, many precautions, such as quarantine practices, social distance rules, distance education, flexible working hours have been taken and the lives of individuals have changed greatly. One of the groups that have been significantly influenced by this process is university students. The primary purpose of this study is to determine the ways in which university students cope with the outbreak and to understand the role of psychological flexibility. There were 457 university students in the study. Participants completed an online questionnaire form comprising items relevant to their coping strategies and psychological flexibility levels. Results revealed that participants used transcendental coping the most while relational coping the least. Additionally, psychological inflexibility negatively predicted transcendental, behavioral, and relational coping behaviors. These results revealed the fact that psychological flexibility is an important mechanism that channels students’ coping behaviors in such a critical process.
  🖺 Full Text HTML: Strategies of University Students to Cope with COVID-19 and the Role of Psychological Flexibility
• Disentangling dynamic affect trajectories for distinct depression courses during the COVID-19 pandemic -
  Background. Why does adversity lead to mental health complaints in some, but not others? Individual differences in the development of depressive complaints are related to the regulation of affect states. The COVID-19 pandemic has caused a prolonged period of perturbations to the daily lives of people across the globe, providing an unparalleled opportunity to investigate how fluctuations in positive and negative affect relate to the evolution of mood complaints. Methods. 228 participants from the Boston College daily sleep and well-being survey completed at least 20 assessments of positive and negative affect and depression complaints between March 20th 2020 and June 26th 2020. We explored affect trajectories throughout this period and estimated longitudinal multilevel network models. Furthermore, we investigated how individual network structures relate to changes in depression severity over time. Results. On average, positive affect was reported somewhat higher than negative affect. However, when separating affect trajectories based on the individuals’ depressive complaints, we identified that individuals consistently experiencing depressive complaints report higher levels of negative affect compared with positive affect. Contrary, individuals consistently reporting no depressive complaints show opposite results. Furthermore, we found many and strong associations in the multilevel network between the distinct affect states and depressive complaints. Lastly, we established that the higher the connectivity of an individual’s network, the larger their change in depressive complaints is. Conclusions. We conclude that affect fluctuations are directly related to the development of depressive complaints, both within- and across individuals, and both within a single measurement moment and over time.
  🖺 Full Text HTML: Disentangling dynamic affect trajectories for distinct depression courses during the COVID-19 pandemic
• Robust induction of B cell and T cell responses by a third dose of inactivated SARS-CoV-2 vaccine -

  SARS-CoV-2 inactivated vaccines have shown remarkable efficacy in clinical trials, especially in reducing severe illness and casualty. However, the waning of humoral immunity over time has raised concern over the durability of immune memory following vaccination. Thus, we conducted a non-randomized trial among the healthcare professionals (HCWs) to investigate the long-term sustainability of SARS-CoV-2-specific B cells and T cells stimulated by inactivated vaccines and the potential need for a third booster dose. Although neutralizing antibodies elicited by the standard two- dose vaccination schedule dropped from a peak of 29.3 AU/ml to 8.8 AU/ml 5 months after the second vaccination, spike- specific memory B and T cells were still detectable, forming the basis for a quick recall response. As expected, the faded humoral immune response was vigorously elevated to 63.6 AU/ml by 7.2 folds 1 week after the third dose along with abundant spike-specific circulating follicular helper T cells in parallel. Meanwhile, spike-specific CD4+ and CD8+ T cells were also robustly elevated by 5.9 and 2.7 folds respectively. Robust expansion of memory pools by the third dose potentiated greater durability of protective immune responses. Another key finding in this trial was that HCWs with low serological response to 2 doses were not truly non-responders but fully equipped with immune memory that could be quickly recalled by a third dose even 5 months after the second vaccination. Collectively, these data provide insights into the generation of long-term immunological memory by the inactivated vaccine, which could be rapidly recalled and further boosted by a third dose.

  🖺 Full Text HTML: Robust induction of B cell and T cell responses by a third dose of inactivated SARS-CoV-2 vaccine
• Relating psychiatric symptoms and self-regulation during the COVID-19 crisis -
  Disruptions of self-regulation are a hallmark of numerous psychiatric disorders. Here, we examine the relationship between transdiagnostic dimensions of psychopathology and changes in self-regulation in the early phase of the COVID-19 pandemic. We used data-driven approach on a large number of cognitive tasks and self-reported surveys in training datasets. Then we derived measures of self-regulation and psychiatric functioning in an independent population sample (N = 102) tested both before and after the onset of the COVID-19 pandemic, when the restrictions in place represented a threat to mental health and forced people to flexibly adjust to modifications of daily routines. We found independent relationships between transdiagnostic dimensions of psychopathology and longitudinal alterations in specific domains of self-regulation defined using the drift diffusion model. Compared to the period preceding the onset of the pandemic, a symptom dimension related to anxiety and depression was characterized by a more cautious behavior, indexed by the need to accumulate more evidence before making a decision. Instead, social-withdrawal related to faster non-decision processes. Self-reported measures of self-regulation predicted variance in psychiatric symptoms both concurrently and prospectively, revealing the psychological dimensions relevant for separate transdiagnostic dimensions of psychiatry, but tasks did not. Taken together, our study shows that self-regulation can be affected depending on the interaction between external events and trait-like vulnerabilities and suggests that the study of cognition needs to take into account the dynamic nature of real-world events as well as within-subject variability over time.
  🖺 Full Text HTML: Relating psychiatric symptoms and self-regulation during the COVID-19 crisis
• Potential COVID-19 Immunomodulators and Beyond: NSAIDs Might Inhibit SARS CoV-2 ORF Proteins Induced Caspase Activation, Necroptosis and Endoplasmic Reticulum Stress. -
  Updated, peer reviewed and published https://link.springer.com/article/10.1007/s10787-021-00896-7#Sec7 We have previously suggested numerous immunomodulatory and anti-inflammatory benefits when NSAIDs are administered as first choice therapy early in management of COVID-19 and in this manuscript we add several additional clues and it is really unfortunate that for more than one year of relentless struggle, this call is not yet adopted to save precious lives that are succumbed every day.
  🖺 Full Text HTML: Potential COVID-19 Immunomodulators and Beyond: NSAIDs Might Inhibit SARS CoV-2 ORF Proteins Induced Caspase Activation, Necroptosis and Endoplasmic Reticulum Stress.
• NSAIDs/Nitazoxanide/Azithromycin Immunomodulatory COVID Protocol Might Inhibit SARS CoV-2 Replication Through Disruption of NF-κB Signaling -
  Updated, peer reviewed and published https://link.springer.com/article/10.1007/s10787-021-00896-7#Sec7 In March 2020, I’ve sent a correspondence to NEJM (20-06753) calling the claims that led the world to avoid non-steroidal anti- inflammatory drugs in COVID-19 management as a scam and it was rejected by this journal as well as more than a dozen of other journals until published almost six months later at the reputable InflammoPharmacology. In April 2020, a concept paper was rapidly published as a letter to the editor favoring nitazoxanide over ivermectin for management of COVID-19 together with azithromycin. Since then, a protocol has evolved to safely manage dozens of pediatric, geriatric, adult and pregnant COVID-19 patients and it was rejected by dozens of journals since May 2020 (20-19376) and eventually it was published in August 2021 only after publishing several papers to justify its academic basis in highly reputable journals. I repeat my long-ignored claim NSAIDs/Nitazoxanide/Azithromycin immunomodulatory protocol (Kelleni’s Protocol) a game-changer that might end this pandemic safely and immediately and, in this manuscript, I’m adding more recent evidence that justify my claim.
  🖺 Full Text HTML: NSAIDs/Nitazoxanide/Azithromycin Immunomodulatory COVID Protocol Might Inhibit SARS CoV-2 Replication Through Disruption of NF-κB Signaling
• NSAIDs, SARS CoV-2 ORF Proteins, Caspases, and CARD14: Solving the Mystery of COVID-19 and Beyond -
  Updated, peer reviewed and published https://link.springer.com/article/10.1007/s10787-021-00896-7#Sec7 In this manuscript we further build on our previous suggested potential beneficial effects of using NSAIDs as first choice drugs in COVID-19 management while discussing the role that SARS CoV-2 ORF proteins induced caspases play in the pathophysiology of SARS CoV-2 infection. Moreover, we postulate that CARD 14, a caspase recruitment domain-containing protein of the membrane-associated guanylate kinases family, mutations might share a role in development of severe and critical COVID-19.
  🖺 Full Text HTML: NSAIDs, SARS CoV-2 ORF Proteins, Caspases, and CARD14: Solving the Mystery of COVID-19 and Beyond
• Measuring the effects of misinformation exposure on behavioural intentions -
  Misinformation has been a pressing issue since the beginning of COVID-19 pandemic, threatening our ability to effectively act on the crisis. More recently, the availability of vaccines in developed countries has not always translated into high vaccination rates, with online misinformation often presented as the culprit. Yet little is known about the actual effects of fake news on behavioural intentions. Does exposure to misinformation about COVID-19 vaccines indeed affects people’s intentions to receive such a vaccine? This paper attempts to answer this question through three preregistered experiments (N=3463). In Study 1, participants (n=1269) were exposed to fabricated pro- or anti- vaccine information or to neutral true information, and then asked about their intentions to get vaccinated, alongside a few other behavioural intentions. In Study 2, participants (n=1863) were exposed to true pro- and anti-vaccine information, while Study 3 (n=1548) compared the effects of single and multiple exposures to novel misinformation about COVID-19 vaccines. The results showed that exposure to false information on the vaccines did not affect the participants’ intentions to get vaccinated, even when multiple exposures led them to believe that the headlines were more accurate than in the single exposure conditions. An exploratory meta-analysis of studies 1 and 3 (n=2683) showed that exposure to false information about COVID-19 vaccines, regardless of whether it was in favour of or against vaccines, increased vaccination intentions. We conclude by cautioning researchers against equating exposure to misinformation or perceived accuracy of false news with actual behaviours.
  🖺 Full Text HTML: Measuring the effects of misinformation exposure on behavioural intentions
• The potential crucial role of COX-1 inhibition and/or Aspirin triggered lipoxins and resolvins in amelioration of COVID-19 mortality -
  Updated, peer reviewed and published https://link.springer.com/article/10.1007/s10787-021-00896-7#Sec7 Aspirin has been recently suggested to be independently associated with reduced risk of mechanical ventilation, ICU admission and in-hospital mortality of COVID-19. However, we claim that the molecular interpretation of these important results was not scientifically valid and we provide our academic interpretation that is also basing on our real-life practice using non-steroidal anti-inflammatory drugs in management of COVID-19 and we suggest that inhibition of COX-1 and/or COX-2 enzymes might play a life saving role in COVID-19 management and we further discuss the potential of aspirin triggered lipoxins and resolivns in the same context.
  🖺 Full Text HTML: The potential crucial role of COX-1 inhibition and/or Aspirin triggered lipoxins and resolvins in amelioration of COVID-19 mortality
• Synthesis of High-Resolution Research-Quality MRI Data from Clinical MRI Data in Patients with COVID-19 -

  Pathophysiological mechanisms of neurological disorders in patients with coronavirus disease 2019 (COVID-19) are poorly understood, partly because of a lack of high-resolution neuroimaging data. We applied SynthSR, a convolutional neural network that synthesizes high-resolution isotropic research-quality data from thick-slice clinical MRI data, to a cohort of 11 patients with severe COVID-19. SynthSR successfully synthesized T1-weighted MPRAGE data at 1 mm spatial resolution for all 11 patients, each of whom had at least one brain lesion. Correlations between volumetric measures derived from synthesized and acquired MPRAGE data were strong for the cortical grey matter, subcortical grey matter, brainstem, hippocampus, and hemispheric white matter (r=0.84 to 0.96, p≤0.001), but absent for the cerebellar white matter and corpus callosum (r=0.04 to 0.17, p>0.61). SynthSR creates an opportunity to quantitatively study clinical MRI scans and elucidate the pathophysiology of neurological disorders in patients with COVID-19, including those with focal lesions.

  🖺 Full Text HTML: Synthesis of High-Resolution Research-Quality MRI Data from Clinical MRI Data in Patients with COVID-19
• Population-level changes in the mental health of UK workers during the COVID-19 pandemic: A longitudinal study using Understanding Society -

  Objectives The COVID−19 pandemic has substantially affected workers mental health. We investigated changes in UK workers mental health by industry, social class, and occupation and differential effects by UK country of residence, gender and age. Methods We used representative Understanding Society data from 6,474 adults (41,207 observations) in paid employment who participated in pre−pandemic (2017−2020) and at least one COVID-19 survey. The outcome was psychological distress (General Health Questionnaire-12; score≥4). Exposures were industry, social class and occupation and are examined separately. Mixed−effects logistic regression was used to estimate relative (OR) and absolute (%) increases in distress before and during pandemic. Differential effects were investigated for UK countries of residence (Non−England/England), gender (Male/female), and age (Younger/Older) using 3−way interaction effects. Results Psychological distress increased in relative terms most for professional, scientific and technical (OR:3.15, 95% CI 2.17−4.59) industry in the pandemic versus pre−pandemic period. Absolute risk increased most in hospitality (+11.4%). For social class, small employers/self−employed were most affected in relative and absolute terms (OR:3.24, 95% CI 2.28− 4.63; +10.3%). Across occupations Sales and customer service (OR:3.01, 95% CI 1.61− 5.62; +10.7%) had the greatest increase. Analysis with 3−way interactions showed considerable gender differences, while for UK country of residence and age results are mixed. Conclusions Psychological distress increases during the COVID−19 pandemic were concentrated among professional and technical and hospitality industries, small employers/self−employed and sales and customers service workers. Female workers often exhibited greater differences in risk by industry and occupation. Policies supporting these industries and groups are needed.

  🖺 Full Text HTML: Population-level changes in the mental health of UK workers during the COVID-19 pandemic: A longitudinal study using Understanding Society
• Homeworking during the COVID-19 pandemic: Lessons for research and practice for sustainable (home)working in government -
  During the COVID-19 pandemic, public servants in many countries were mandated to work from home. The unprecedented nature of the situation entailed considerable challenges for providing adequate HR support. In this study, we explored how Dutch public servants experienced mandatory homeworking by conducting a template analysis. Based on in-depth analyses of 985 written accounts, we inductively expanded an a priori template derived from the Job-Demands-Resource (JD-R) framework, to understand and analyze how public servants experienced their new situation. We found that components of mandatory homeworking trigger different experienced resources and demands with divergent consequences for different employees. Our study raises awareness about the effects of contextual factors, specifically personal background characteristics and working conditions, that are important to understand their divergent experiences with mandatory homeworking. Our findings are translated into propositions that extend the JD-R model. We end with lessons to create sustainable (home)working conditions in government.
  🖺 Full Text HTML: Homeworking during the COVID-19 pandemic: Lessons for research and practice for sustainable (home)working in government
• Rapid evaluation of COVID-19 vaccine effectiveness against VOC/VOIs by genetic mismatch -

  Timely evaluation of the protective effects of COVID-19 vaccines is challenging but urgently needed to inform the pandemic control planning. Based on vaccine efficacy/effectiveness (VE) data of 11 vaccine products and 297,055 SARS-CoV-2 sequences collected in 20 regions, we analyzed the relationship between genetic mismatch of circulating viruses against the vaccine strain and VE. Variations from technology platforms are controlled by a mixed-effects model. We found that the genetic mismatch measured on the RBD is highly predictive for vaccine protection and accounted for 72.0% (p-value < 0.01) of the VE change. The NTD and S protein also demonstrate significant but weaker per amino acid substitution association with VE (p-values < 0.01). The model is applied to predict vaccine protection of existing vaccines against new genetic variants and is validated by independent cohort studies. The estimated VE against the delta variant is 79.3% (95% prediction interval: 67.0 - 92.1) using the mRNA platform, and an independent survey reported a close match of 83.0%; against the beta variant (B.1.351) the predicted VE is 53.8% (95% prediction interval: 39.9 - 67.4) using the viral-vector vaccines, and an observational study reported a close match of 48.0%. Genetic mismatch provides an accurate prediction for vaccine protection and offers a rapid evaluation method against novel variants to facilitate vaccine deployment and public health responses.

  🖺 Full Text HTML: Rapid evaluation of COVID-19 vaccine effectiveness against VOC/VOIs by genetic mismatch
• Covid-19 vaccination coverage and break through infections in urban slums of Bengaluru, India: A cross sectional study. -

  Background: The ongoing pandemic of Corona virus disease 2019(covid 19) is caused by severe acute respiratory syndrome Corona virus 2(SAR COV 2). The world health organization declared it as public health emergency of international concern on January 2020 and later declared as pandemic on 11 March 2020.One of the high risk groups for COVID 19 disease are people residing in urban overcrowded slums and as most of the population is migrant, they are less aware of the pandemic and have less access to health care facilities. Vaccinating these high risk groups can decrease disease burden and control the ongoing pandemic. Objectives: 1] To estimate COVID 19 vaccination coverage 2] To assess the factors responsible for COVID 19 vaccination coverage and vaccine hesitancy 3] To study AEFI pattern following COVID 19 vaccination 4] To determine the prevalence of breakthrough infections after COVID 19 Vaccination in urban slums of Bengaluru, India. Methodology: A community based cross sectional study was conducted in Urban slums belonging to Urban Health and Training Centre, Department of community medicine, Akash Institute of Medical Sciences and Research Centre, Bengaluru Rural District, Karnataka, India. After obtaining Institutional ethical clearance and informed consent from study participants, data was collected from 1638 participants, fulfilling inclusion criteria using a predesigned, pretested, structured questionnaire. Data was entered in Microsoft excel and analyzed using SPSS version 24. Chi square test and Fischers exact test was applied and p <0.05 considered as statistically significant. Results: In the present study, 35.5% (583 out of 1638) of the study participants had taken COVID Vaccine, of which 533 (91.42%) were partially vaccinated and remaining 50 (8.5%) were fully Vaccinated. Majority i.e. 98.45% have taken vaccine at Govt health centers. 63.65% vaccinated with Covishield reported adverse events, whereas 18.6% vaccinated with Covaxin reported adverse events. Adverse events were more likely to be reported by women (74.7%) compared to men (58.6%) , this observation was consistent across all age groups. Vaccination coverage was high among 18 to 45 years age group (37.75%), males (64.86%), Christians (47.05%) followed by Hindus (43.56%), graduates (95.67%), clerical and skilled workers (70.75%), Upper middle socioeconomic class (72.41%). This difference was statistically significant. Our study reported Break through infections in 7 out of total 583 vaccinated with a prevalence of 1.2%. The break through infections was very high among partially vaccinated (85.71%) as compared to fully vaccinated individuals (14.28%). This was observed among those vaccinated with Covaxin only. Conclusion: The COVID 19 vaccine coverage was low in urban slums. The prevalence of Break through infections in our study was higher as compared to available data/reports in the country. Break through infections was very high among partially vaccinated as compared to fully vaccinated individuals. This study on break through infections on COVID vaccination is first study in South India on general population. The most important factor for vaccine hesitancy is the occurrence of mild or serious adverse effects following immunization, and this may be the biggest challenge in the global response against the pandemic. Key words: COVID 19 vaccination, Break through infections, Vaccine hesitancy, Adverse events COVID vaccination, Urban slums

  🖺 Full Text HTML: Covid-19 vaccination coverage and break through infections in urban slums of Bengaluru, India: A cross sectional study.
• Exploring the Temporal Dynamics of County-Level Vulnerability Factors on COVID-19 Outcomes -

  As the outbreak of COVID-19 has become a severe worldwide pandemic, every country fights against the spread of this deadly disease with incredible efforts. There are numerous researches along with every conceivable dimension for COVID-19. Among these researches, different demographic and contextual factors of populations and communities also play an essential role in providing more information for decision-makers. This paper mainly utilizes existing data on county contextual factors at the United States county-level to develop a model that can capture the dynamic trajectory of COVID-19 (i.e., cases) and its impacts across the United States. Moreover, our methods applied to contextual data achieves better results compared with existing measures of vulnerability.

  🖺 Full Text HTML: Exploring the Temporal Dynamics of County-Level Vulnerability Factors on COVID-19 Outcomes

From Clinical Trials

• Study to Evaluate the Effects of RO7496998 (AT-527) in Non-Hospitalized Adult and Adolescent Participants With Mild or Moderate COVID-19 - Condition:   COVID-19
  Interventions:   Drug: RO7496998;   Drug: Placebo
  Sponsor:  
  Hoffmann-La Roche
  Suspended

• Mesenchymal Stem Cell Secretome In Severe Cases of COVID-19 - Condition:   COVID-19
  Interventions:   Biological: Injection of secretome - mesenchymal stem cell;   Other: Placebo;   Drug: Standard treatment of Covid-19
  Sponsor:   Indonesia University
  Completed

• Allogenic UCMSCs as Adjuvant Therapy for Severe COVID-19 Patients - Condition:   Covid 19
  Interventions:   Biological: Normoxic Allogenic UCMSC;   Other: Normal saline solution
  Sponsors:   Kementerian Riset dan Teknologi / Badan Riset dan Inovasi Nasional, Indonesia;   Dr. Moewardi General Hospital, Surakarta, Indonesia;   Dr. Sardjito General Hospital, Yogyakarta, Indonesia;   Dr. Hasan Sadikin General Hospital, Bandung, Indonesia;   PT Bifarma Adiluhung
  Recruiting

• Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles Infusion Treatment for Mild-to-Moderate COVID-19: A Phase II Clinical Trial - Condition:   COVID-19
  Intervention:   Drug: ExoFlo
  Sponsor:   Direct Biologics, LLC
  Recruiting

• Physical Fitness in Young Healthy Adults After COVID-19 Infection - Condition:   COVID-19
  Interventions:   Other: Physical Activity Level;   Other: Evaluation of knee extension and elbow flexion muscle strength;   Other: Evaluation of functional strength of trunk muscles;   Other: Muscle Endurance;   Other: Flexibility;   Other: Balance;   Other: Fatigue
  Sponsor:  
  Baskent University
  Enrolling by invitation

• The South Proxa-Rescue AndroCoV Trial Against COVID-19 - Condition:   COVID-19
  Interventions:   Drug: Proxalutamide;   Drug: Placebo
  Sponsors:   Corpometria Institute;   Hospital da Brigada Militar de Porto Alegre, Porto Alegre, Brazil;   Hospital Arcanjo Sao Miguel, Gramado, Brazil;   Hospital Unimed Chapeco, Chapeco, Brazil
  Completed

• Vitamin D Supplementation and Clinical Improvement in COVID-19 - Condition:   COVID-19
  Interventions:   Dietary Supplement: Vitamin D3 10000 IU;   Dietary Supplement: Vitamin D3 1000 IU
  Sponsor:   Bumi Herman
  Completed

• Feasibility Pilot Clinical Trial of Omega-3 Supplement vs. Placebo for Post Covid-19 Recovery Among Health Care Workers - Condition:   COVID-19
  Interventions:   Drug: Omega-3 (EPA+DHA);   Drug: Placebo
  Sponsor:   Hackensack Meridian Health
  Not yet recruiting

• Controlled Trial of Angiotensin Receptor Blocker (ARB) & Chemokine Receptor Type 2 (CCR2) Antagonist for the Treatment of COVID-19 - Conditions:   COVID-19;   SARS-CoV2 Infection
  Interventions:   Drug: Candesartan Cilexetil;   Drug: Repagermanium;   Drug: Candesartan Placebo;   Drug: Repagermanium Placebo
  Sponsors:  
  University of Sydney;   The George Institute for Global Health, India
  Not yet recruiting

• Partnerships to Address COVID-19 Inequities - Condition:   COVID-19
  Interventions:   Behavioral: Crowdsourced campaign package;   Behavioral: Standard information
  Sponsor:   Duke University
  Not yet recruiting

• Study to Evaluate the inHaled Recombinant COVID-19 Vaccine (Adenovirus Type 5 Vector) On the Protective-Efficacy in Adults (SeiHOPE) - Condition:   COVID-19
  Interventions:   Biological: Recombinant COVID-19 vaccine (adenovirus type 5 vector) for Inhalation (Ad5-nCoV-IH);   Biological: Placebo
  Sponsors:   CanSino Biologics Inc.;   Beijing Institute of Biotechnology
  Not yet recruiting

• Pharmacokinetics, Pharmacodynamics, and Safety of Single-dose Sotrovimab in High-risk Pediatric Participants With Mild to Moderate COVID-19 - Condition:   COVID-19
  Intervention:   Biological: Sotrovimab
  Sponsors:  
  GlaxoSmithKline;   Vir Biotechnology, Inc.
  Not yet recruiting

• PREVENT-COVID-19: A Q-Griffithsin Intranasal Spray - Condition:   COVID-19 Prevention
  Interventions:   Drug: Q-Griffithsin;   Other: Placebo
  Sponsors:   Kenneth Palmer;   United States Department of Defense
  Recruiting

• Inhaled Recombinant Non-immunogenic Staphylokinase vs Placebo in Patients With COVID-19 - FORRIF Trial - Condition:   COVID-19
  Interventions:   Drug: Recombinant nonimmunogenic staphylokinase;   Drug: Placebo
  Sponsors:   Supergene, LLC;   Russian Academy of Medical Sciences
  Not yet recruiting

• Nutritional Supplementation of Vitamin D, Quercetin and Curcumin With Standard of Care for Managing Mild Early Symptoms of COVID-19 - Condition:   COVID-19
  Interventions:   Drug: Standard of care;   Dietary Supplement: Investigational treatment
  Sponsor:   King Edward Medical University
  Recruiting

From PubMed

• In Silico Analysis of Bacteriocins from Lactic Acid Bacteria Against SARS-CoV-2 - The COVID-19 pandemic caused by a novel coronavirus (SARS-CoV-2) is a serious health concern in the twenty-first century for scientists, health workers, and all humans. The absence of specific biotherapeutics requires new strategies to prevent the spread and prophylaxis of the novel virus and its variants. The SARS-CoV-2 virus shows pathogenesis by entering the host cells via spike protein and Angiotensin-Converting Enzyme 2 receptor protein. Thus, the present study aims to compute the binding…

• SARS-CoV-2 Spike Protein-Induced Interleukin 6 Signaling Is Blocked by a Plant-Produced Anti-Interleukin 6 Receptor Monoclonal Antibody - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the current COVID-19 pandemic, has caused more than 4.5 million deaths worldwide. Severe and fatal cases of COVID-19 are often associated with increased proinflammatory cytokine levels including interleukin 6 (IL-6) and acute respiratory distress syndrome. In this study, we explored the feasibility of using plants to produce an anti-IL-6 receptor (IL-6R) monoclonal antibody (mAb) and examined its utility in…

• Killing Two Birds with One Stone by Administration of Soluble ACE2: A Promising Strategy to Treat Both Cardiovascular Diseases and SARS-CoV-2 Infection - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters host cells mainly by the angiotensin converting enzyme 2 (ACE2) receptor, which can recognize the spike (S) protein by its extracellular domain. Previously, recombinant soluble ACE2 (sACE2) has been clinically used as a therapeutic treatment for cardiovascular diseases. Recent data demonstrated that sACE2 can also be exploited as a decoy to effectively inhibit the cell entry of SARS-CoV-2, through blocking SARS-CoV-2 binding…

• Broad Spectrum Antiviral Properties of Cardiotonic Steroids Used as Potential Therapeutics for Emerging Coronavirus Infections - Cardiotonic steroids are steroid-like natural compounds known to inhibit Na^(+)/K(+)-ATPase pumps. To develop a broad- spectrum antiviral drug against the emerging coronavirus infection, this study assessed the antiviral properties of these compounds. The activity of seven types of cardiotonic steroids against the MERS-CoV, SARS-CoV, and SARS-CoV-2 coronavirus varieties was analyzed using immunofluorescence antiviral assay in virus-infected cells. Bufalin, cinobufagin, and telocinobufagin showed…

• A Comprehensive Review about the Molecular Structure of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS- CoV-2): Insights into Natural Products against COVID-19 - In 2019, the world suffered from the emergence of COVID-19 infection, one of the most difficult pandemics in recent history. Millions of confirmed deaths from this pandemic have been reported worldwide. This disaster was caused by SARS- CoV-2, which is the last discovered member of the family of Coronaviridae. Various studies have shown that natural compounds have effective antiviral properties against coronaviruses by inhibiting multiple viral targets, including spike proteins and viral enzymes….

• Synthesis, Antimicrobial, Anticancer, PASS, Molecular Docking, Molecular Dynamic Simulations & Pharmacokinetic Predictions of Some Methyl β-D-Galactopyranoside Analogs - A series of methyl β-D-galactopyranoside (MGP, 1) analogs were selectively acylated with cinnamoyl chloride in anhydrous N,N-dimethylformamide/triethylamine to yield 6-O-substitution products, which was subsequently converted into 2,3,4-tri-O-acyl analogs with different acyl halides. Analysis of the physicochemical, elemental, and spectroscopic data of these analogs revealed their chemical structures. In vitro antimicrobial testing against five bacteria and two fungi and the prediction of…

• Curcumin Inhibits In Vitro SARS-CoV-2 Infection In Vero E6 Cells through Multiple Antiviral Mechanisms - Due to the scarcity of therapeutic approaches for COVID-19, we investigated the antiviral and anti-inflammatory properties of curcumin against SARS-CoV-2 using in vitro models. The cytotoxicity of curcumin was evaluated using MTT assay in Vero E6 cells. The antiviral activity of this compound against SARS-CoV-2 was evaluated using four treatment strategies (i. pre-post infection treatment, ii. co-treatment, iii. pre-infection, and iv. post-infection). The D614G strain and Delta variant of…

• Jeopardy of COVID-19: Rechecking the Perks of Phytotherapeutic Interventions - The novel coronavirus disease (COVID-19), the reason for worldwide pandemic, has already masked around 220 countries globally. This disease is induced by Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2). Arising environmental stress, increase in the oxidative stress level, weak immunity and lack of nutrition deteriorates the clinical status of the infected patients. Though several researches are at its peak for understanding and bringing forward effective therapeutics, yet there is…

• Natural Apocarotenoids and Their Synthetic Glycopeptide Conjugates Inhibit SARS-CoV-2 Replication - The protracted global COVID-19 pandemic urges the development of new drugs against the causative agent SARS-CoV-2. The clinically used glycopeptide antibiotic, teicoplanin, emerged as a potential antiviral, and its efficacy was improved with lipophilic modifications. This prompted us to prepare new lipophilic apocarotenoid conjugates of teicoplanin, its pseudoaglycone and the related ristocetin aglycone. Their antiviral effect was tested against SARS-CoV-2 in Vero E6 cells, using a cell…

• Antiviral Activities of Andrographolide and Its Derivatives: Mechanism of Action and Delivery System - Andrographispaniculata (Burm.f.) Nees has been used as a traditional medicine in Asian countries, especially China, India, Vietnam, Malaysia, and Indonesia. This herbaceous plant extract contains active compounds with multiple biological activities against various diseases, including the flu, colds, fever, diabetes, hypertension, and cancer. Several isolated compounds from A. paniculata, such as andrographolide and its analogs, have attracted much interest for their potential treatment against…

• Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells - (1) Background: There is a strong need for prevention and treatment strategies for COVID-19 that are not impacted by SARS-CoV-2 mutations emerging in variants of concern. After virus infection, host ER resident sigma receptors form direct interactions with non-structural SARS-CoV-2 proteins present in the replication complex. (2) Methods: In this work, highly specific sigma receptor ligands were investigated for their ability to inhibit both SARS-CoV-2 genome replication and virus induced…

• Insights into the SARS-CoV-2-Mediated Alteration in the Stress Granule Protein Regulatory Networks in Humans - The rapidly and constantly evolving coronavirus, SARS-CoV-2, imposes a great threat to human health causing severe lung disease and significant mortality. Cytoplasmic stress granules (SGs) exert anti-viral activities due to their involvement in translation inhibition and innate immune signaling. SARS-CoV-2 sequesters important SG nucleator proteins and impairs SG formation, thus evading the host response for efficient viral replication. However, the significance of SGs in COVID-19 infection…

• The Impact of Socialisation on Children’s Prosocial Behaviour. A Study on Primary School Students - CONCLUSIONS: The results are relevant and useful for the study of trends in prosocial behaviours among children. Family education level, individual status, peer interactions and social conditionings are variables that highly influence this multidimensional phenomenon. Further research is needed, including the definition of new measures and indicators concerning the context where children live and interact with others, with the aim of designing interventions aimed at facilitating relational…

• Impacts of p97 on Proteome Changes in Human Cells during Coronaviral Replication - Human coronavirus (HCoV) similar to other viruses rely on host cell machinery for both replication and to spread. The p97/VCP ATPase is associated with diverse pathways that may favor HCoV replication. In this study, we assessed the role of p97 and associated host responses in human lung cell line H1299 after HCoV-229E or HCoV-OC43 infection. Inhibition of p97 function by small molecule inhibitors shows antiviral activity, particularly at early stages of the virus life cycle, during virus…

• Xanthohumol Is a Potent Pan-Inhibitor of Coronaviruses Targeting Main Protease - Coronaviruses cause diseases in humans and livestock. The SARS-CoV-2 is infecting millions of human beings, with high morbidity and mortality worldwide. The main protease (M^(pro)) of coronavirus plays a pivotal role in viral replication and transcription, which, in theory, is an attractive drug target for antiviral drug development. It has been extensively discussed whether Xanthohumol is able to help COVID-19 patients. Here, we report that Xanthohumol, a small molecule in clinical trials from…

From Patent Search

• P2P 네트워크를 이용한 내장된 화상회의 시스템 - 본 발명은 P2P 네트워크를 이용한 내장된 화상회의 시스템에 관한 것으로, 상태표시부(1), 영상송출부(2), 제어부(3), 광고부(4), 입력부(5)를 포함한다. - link

• A DOORBELL SYSTEM FOR MONITORING AND RECORDING A PHYSIOLOGICAL DATA OF A PERSON - AbstractTitle: A doorbell system for monitoring and recording a physiological data of a person The present invention provides a doorbell system 500 for monitoring and recording a physiological data of a person. The doorbell system 500 having a transmitter module 100 and a receiving module 200. The transmitter module 100 is having a TOF sensor module 110, an ultrasound detector 120, and an infrared detector 130. Further, a speech recognition system 150, a facial recognition system 160, and a temperature detector 190 are provided for recognizing speech, face, and temperature of the person by comparing pre-stored data. A controlling module 180 is set with a predefined commands for communicating with the transmitter module 100 and receiving module 200. The collected facial and speech data is compared and matched with the pre-stored data then the temperature detector 190 triggers and the door opens when the captured body temperature of the person is matched within the predefined range of temperature.Figure 1 - link

• A study of contemporary trends in investing patterns, household savings, and economic investment. - Because household savings and household investments are intertwined and interdependent, they are discussed briefly in this paper. Household savings account for more than half of a country’s capital formation, which fluctuates due to a variety of economic factors such as inflation and interest rates. Households should gradually shift their savings and investments from physical assets to financial assets to avoid a sudden change in wealth. They should also save and invest using a variety of platforms. Trends in investing and saving will be easier to track and measure this way. This year’s domestic saving rate in India is 2.3 percent lower than last year’s and 1.2 percent lower than the year before. Since 2011, general domestic savings have been steadily declining, with the trend continuing into the following year. According to official data, the GDP in 2020 shrank by 23.9%, the least in previous years and the least since the Covid-19 pandemic in previous years. As a result, the information presented in this paper is drawn from and evaluated from other sources - link

• PROLIPOSOMAL DRY POWDER INHALER OF REMDESIVIR - The present invention is related to Proliposomal Dry Powder Inhaler of Remdesivir and its method thereof for the treatment of viral infections such Coronaviridae (including COVID-19 infection). - link

• Use of Diminazene Aceturate, Xanthenone, ACE 2 activators or analogs for the Treatment and therapeutic use of COVID-19 on human patients. - - link

• ACTIVE RIDER SAFETY SYSTEM FOR TWO WHEELERS - The present invention relates to an active rider safety system for two wheelers comprising, a protective case equipped by a user for riding, where the case is integrated with multiple piezoelectric sensor that determines fastening of the case by user, a processing unit linked to the sensor, where the unit detects absence of case upon fetching data from the sensor below a threshold value and thereby terminates operation of ignition by stopping a coupled motor operated via a radio frequency module, an alcohol detection sensor that detects presence of alcohol and send data to processing unit, a temperature sensor that measures temperature of the user, an accelerometer sensor that activates upon ignition us tuned on to determine presence of a crash and a navigation module that via communication module sends location of user to pre saved users and concerned authorities. - link

• Anti-SARS-CoV-2 antibodies and uses thereof I - - link

• Anti-SARS-CoV-2 antibodies and uses thereof II - - link

• Secured Health monitoring system using cloud computing - As used in public health surveillance, the invention generally relates to remote health monitoring systems with cloud computing. This is particularly relevant about a multi-user remote health monitoring system that can detect and gather data from healthcare professionals on the ground and systems in laboratories and hospitals to help the public health sector. It is possible to utilize the system for tracking, monitoring, and collecting patient data and for querying and collecting more information on the health of the people. - link

• Bst DNA聚合酶重组突变体、其编码DNA及超快磁珠LAMP检测方法 - 本发明在野生型Bst DNA聚合酶序列上进行了Ser358Asp、Thr480Asn、Asp533Glu、Ala539Gly几个点位的突变，然后将进行点突变后的Bst DNA聚合酶的292‑305的氨基酸EGLLKVVRPDTKKV替换成DPLPDLIHPRTLRL，在突变后Bst DNA聚合酶序列的C端融合了一个DNA结合蛋白，在突变后Bst DNA聚合酶序列的N端融合了一个HP47多肽序列（SEQ ID No.17），在HP47多肽序列前面融合了一个CL7‑SUMO‑Tag，得到一种具有高活性和热稳定性的Bst DNA聚合酶重组突变体Super‑Bst（SEQ ID No.16）。Super‑Bst在热稳定性、特异性、链置换能力、延伸能力和逆转录酶活性上得到了显著地提升，能够耐受高盐和各类抑制剂，且可以通过原核表达和亲和纯化大量获得。本发明还公开了其编码DNA，以及一种超快磁珠LAMP检测方法。 - link